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KMID : 0604520110370010067
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 1 p.67 ~ p.73
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The Anti-inflammatory Effect of Green Tea Extract Against Prevotella intermedia
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Min Dae-jin
Yi Sung-won
Lee Sung-Hoon
Kim Seung-Seob
Kim Chan-ho
Lee John-Hwan
Bae Ji-hyun
Kim Han-Gon
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Abstract
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Dental bacteria can cause gum diseases, i.e. gingivitis and periodontitis, by inducing inflammation in human gingiva. Therefore, the most effective way to prevent and treat gum diseases is the control of the inflammatory reactions induced by dental bacteria. Almost all present dental care products contain anti-bacterial agents to eliminate dental bacteria. However, recent studies report that even heat-killed dental bacteria can induce the inflammation responses in oral cells. Therefore, the method using anti-bacterial agents should be improved for better anti-inflammatory effect and the effective natural anti-inflammatory substances need to be found. In addition, the mechanisms of gingival inflammation should be elucidated. In this study, we tried to find out the mechanism of the gingival inflammation and effective natural anti-inflammatory substances with human gingival epithelial cells and Prevotella intermedia which is well known as a typical dental bacteria inducing gingivitis and periodontitis. In results, Prevotell intermedia initiated the gingival inflammation response by stimulating gingival epithelial cells to release an inflammatory cytokine, IL-8. Furthermore, the inflammation by Prevotella intermedia is related to COX-2, AP-1, and TNF- pathways. Green tea extract could effectively suppress the inflammatory responses induced by Prevotella intermedia. We find out the effective natural substance for the improvement of gum diseases by studying the mechanism of the gingival inflammation induced by dental bacteria.
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KEYWORD
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Prevotella intermedia, green tea extract, anti-inflammation, gum disease, IL-8
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